3. Do we go back to “normal” with HRT?
Yes, absolutely. However, it depends on the dosage. I always start with a low dose, regardless of the formulation, and then gradually increase it. The goal is for the woman to come back and tell me: “I have the energy I used to, I can sleep well again, my brain and concentration are better, I feel great, and I’ve started exercising because I now have the energy for it.”
When I hear this, I know we’ve found the right dosage. Yes, a woman can feel exactly as she did in her 30s, without any issue.
There’s no reason why women shouldn’t feel like themselves again, as long as there are no contraindications. However, with dosages high enough to achieve this, some form of bleeding is likely—either a proper period or light spotting. I mention this because when we provide a dose that brings these benefits, I recommend introducing a short “window” at the end of each month. I advise patients to stop the treatment for 4 to 5 days during this time to allow the uterus to shed, which will result in either light bleeding or a regular period.
4. What is the difference between synthetic hormones and bioidentical hormones?
I only prescribe bioidentical hormones because I believe they are better suited for long-term use. In my view, women should not stop bioidentical HRT (bHRT) once they reach a certain age, such as 60 or 70. If they stop, they immediately face an increased risk of cardiovascular disease, osteoporosis, Alzheimer’s, and dementia. These risks naturally rise as we age, so why stop taking bHRT, which protects against these conditions, at a time when the risks are already higher?
There is a well-known group of endocrinologists in the US, with prominent schools of thought, though unfortunately, not many gynaecologists are involved. They have continued prescribing bioidentical HRT to women well into their 90s, perhaps at a lower dose, and the women report loving the effects. Personally, I have several women in their early 80s still on HRT, though I prescribe them lower doses than for women in their 50s, often opting for creams.
In the UK, and in most other countries, only two doses of progesterone are available—100mg and 200mg. For this reason, I rely on compounded pharmacies, which unfortunately are not accessible through the NHS. However, any private doctor—whether a GP, gynaecologist, or endocrinologist—can prescribe through these pharmacies and offer lower doses. Even at these lower doses, women notice a marked improvement and feel much better.
“I have the energy I used to, I can sleep well again, my brain and concentration are better, I feel great, and I’ve started exercising because I now have the energy for it.”
There’s also a formulation I don’t typically use but feel is worth mentioning: the vaginal route. Many gynaecologists prescribe vaginal oestradiol, particularly for women experiencing vaginal dryness or recurrent bladder/urinary infections. Oestriol is also excellent for supporting vaginal health. Some gynaecologists even prescribe vaginal progesterone, though I do not, as oral progesterone is more beneficial for the brain, heart, and bones.
When using vaginal oestradiol or oestriol, the initial dose is usually daily for one or two weeks, then reduced to once or twice a week. This is often recommended for women using creams or patches, as these forms of oestradiol may not provide enough coverage for the entire body. In such cases, local bioidentical hormones can offer additional support. However, this is not my preferred method unless the woman requires temporary relief for specific symptoms.
5. How long should you take it for?
As I’ve mentioned, as women age, their risk of cardiovascular disease, osteoporosis, dementia, Alzheimer’s, Lewy body disease, and other degenerative brain diseases increases. So why stop a treatment that helps prevent these conditions? I don’t understand the medical or scientific reasoning behind stopping HRT. As long as the woman is happy to continue and hasn’t developed any side effects, I see no reason to stop HRT.
The dosage can be reduced as the woman ages, particularly if she wishes to stop having periods. Regular follow-ups are crucial to monitor the effects and make adjustments as necessary.
It’s also essential to inform women that they should have a breast examination every year. They should undergo an ultrasound annually and a mammogram every three to four years. In some countries, women are offered an MRI of the breast, which is less aggressive than a mammogram. In London, there are clinics offering thermography, and the technology has greatly improved, providing clear images of the breast.
Additionally, women should be examined by a gynaecologist annually and have an ultrasound of the uterus to check its thickness. It shouldn’t be thicker than it was during their menstrual cycles. It’s important to have breasts and uterus checked every year, not necessarily with a mammogram, but through examination or ultrasound during gynaecological visits.
At the start of treatment, it’s important to assess how the woman’s body detoxifies hormones and provide dietary support and supplements to aid hormone detoxification.
Another key step at the start of treatment is a DEXA scan (bone density analysis). Numerous studies, even before 2001, have shown that bioidentical HRT helps prevent osteopenia and osteoporosis. It’s recommended to check bone density every five years.
If you missed Part 1 of this Q&A, make sure to check it out here for essential insights into hormone replacement therapy (HRT). In addition, you can explore more about Dr. Isabelle Martineau’s expertise in HRT by visiting her website at Medical Art Practice
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